abstract：:The present study reports the biochemical and immunohistochemical findings in the cytosol of a Hürthle cell carcinoma as compared with that of normal thyroid tissue. Sephadex G-200 chromatography of the extract derived from a Hürthle cell carcinoma and from normal thyroid tissue revealed three identical pools. Pool I ...

journal_title：Journal of endocrinological investigation

authors： De Keyser L,Layfield L,Van Herle A,Costin A,Lewin K

更新日期：1984-10-01 00:00:00

abstract：:An equimolar mixture of 3H-E1-S2 and 14C-E1 was injected in one shot into the inferior vena cava near the heart of female Japanese monkey. Following the injection, blood was collected from the aortic arch at intervals of 15 s over a period of 10 min. The concentration of radioactivities in the whole blood and serum wa...

journal_title：Journal of endocrinological investigation

authors： Sakai C,Yamamoto T,Kitawaki J,Yoshiji S,Yasuda J,Yamaki J,Fujii M,Tsukamoto K,Honjo H,Okada H

更新日期：1984-10-01 00:00:00

abstract：:The present study was performed in 30 patients who needed steroid therapy: courses of triamcinolone or DTM 8-15 given orally lasted 30 days. In 15 of these patients glucoactive corticosteroids were administered in combination with 5 micrograms/day of 25OH-vitamin D3 (25OHD3). 47Calcium oral test and 99mTc-MDP kinetics...

journal_title：Journal of endocrinological investigation

authors： Nuti R,Vattimo A,Turchetti V,Righi G

更新日期：1984-10-01 00:00:00

abstract：:Growth hormone (GH) response to provocative tests was compared in normal short children. Seven of 23 children failed to respond to insulin hypoglycemia. Using insulin hypoglycemia followed by L-dopa only 2 of 23 children did not respond and giving bromocriptine combined with insulin hypoglycemia only 1 of 8 children f...

journal_title：Journal of endocrinological investigation

authors： Bazán MC,Domené H,Heinrich JJ,Barontini M,Bergadá C

更新日期：1984-08-01 00:00:00

abstract：:A comparison of peripheral patterns of androstenedione (A), 17 beta-estradiol (E2) and progesterone (P) is reported in ten infertile women during HMG-HCG induction of ovulation, in order to assess the site of ovarian secretion of plasma A and the possible influence on conception. Evidence for both the follicular and l...

journal_title：Journal of endocrinological investigation

authors： Scirpa P,Mango D,Montemurro A,Battaglia F,Cantafio L

更新日期：1984-08-01 00:00:00

abstract：:Prolactin, LH and FSH circadian secretion were studied in a group of 20 boys in various pubertal stages and in 13 normal male adults. Prolactin 24-hour integrated concentration was similar in all groups except in stage 2 boys, in which it was significantly higher with respect to stage 3-4 boys. This pattern was observ...

journal_title：Journal of endocrinological investigation

authors： Minuto F,Barreca A,Ferrini S,Del Monte P,Bernasconi D,Giordano G

更新日期：1984-06-01 00:00:00

abstract：:The effect of an oral dose of 200 or 400 mg sodium valproate (DPA) on ACTH and cortisol secretion was assessed in 11 patients with Cushing's disease (3 bilaterally adrenalectomized), 3 patients with Nelson's syndrome and 6 patients with Addison's disease. In none of the patients examined DPA induced changes in ACTH (a...

journal_title：Journal of endocrinological investigation

authors： Loli P,Berselli ME,Frascatani F,Muratori F,Tagliaferri M

更新日期：1984-04-01 00:00:00

abstract：:Eleven patients with Paget's disease of bone, treated intermittently for 2-4 years with porcine calcitonin (pCT) and clinically resistant to pCT [no modifications of serum alkaline phosphatase (ALP) and urinary hydroxyproline ( uHOP ) during pCT administration] were treated with 0.5-0.25 mg/day of human calcitonin (hC...

journal_title：Journal of endocrinological investigation

authors： Lo Cascio V,Adami S,Galvanini G,Lazzaretto R,Ferrari M,Tartarotti D,Scuro LA

更新日期：1984-04-01 00:00:00

abstract：:Exhaustive graded exercise leads to changes of hormones, carbohydrate, and lipid metabolism in normal controls and obese patients after prolonged starvation. Concomitant with a large increase of plasma catecholamines, insulin concentration is reduced and blood glucose levels slowly increase. More glucose is made avail...

journal_title：Journal of endocrinological investigation

authors： Jakober B,Schmülling RM,Müller PH,Eggstein M

更新日期：1983-12-01 00:00:00

abstract：:Nine chronic male alcoholics presenting with hypogonadism but without overt liver failure were examined under baseline conditions and after acute injection of gonadotropin releasing hormone (GnRH, 100 micrograms iv) and thyrotropin releasing hormone (TRH, 200 micrograms iv), performed at 60 min of a 3-h infusion of sa...

journal_title：Journal of endocrinological investigation

authors： Bertello P,Gurioli L,Faggiuolo R,Veglio F,Tamagnone C,Angeli A

更新日期：1983-12-01 00:00:00

abstract：:The status of the erythrocyte insulin receptor was investigated prior to and during storage at 4C in acid-citrate dextrose (ACD) solution. The receptors on cells that were obtained from both resting and exercised fasting subjects and stored for up to three days in ACD were unchanged as evaluated by both maximal specif...

journal_title：Journal of endocrinological investigation

authors： Robbins PA,Kwan C,Searle GL

更新日期：1983-08-01 00:00:00

abstract：:Plasma levels and 24-h urinary excretion of cyclic AMP and cyclic GMP were measured in 18 patients with hyperthyroidism, 7 patients with hypothyroidism and 25 normal subjects. Mean plasma and urinary levels of both cyclic AMP and cyclic GMP were significantly positive correlations between the serum thyroid hormone lev...

journal_title：Journal of endocrinological investigation

authors： Peracchi M,Bamonti-Catena F,Lombardi L,Reschini E,Toschi V,Maiolo AT,Polli EE

更新日期：1983-06-01 00:00:00

abstract：:The AA. studied the glycometabolic activity of prazosin, a hypotensive drug with an adrenergic blocking activity of alpha-1-selective type. Twenty-two moderately hypertensive subjects were studied. Their ages ranged from 37 to 57 years; 10 of the patients had non-insulin dependent diabetes mellitus. After overnight fa...

journal_title：Journal of endocrinological investigation

authors： Ferlito S,Puleo F,Carrà G,Damante G,Di Vincenzo S,Del Campo F

更新日期：1983-06-01 00:00:00

abstract：:Total and free thyroid hormones (T3, T4, FT3, FT4), TSH and PRL were determined in basal conditions and after stimulation with TRH in 32 patients affected by autonomous thyroid nodules before and after nodulectomy and in 24 control subjects. Only 7 patients were clinically thyrotoxic and thyroid hormone concentrations...

journal_title：Journal of endocrinological investigation

authors： Langer M,Costanza C,Casu AR,Rassu S,Madeddu G

更新日期：1983-06-01 00:00:00

abstract：:The intravenous injection of calcium gluconate (0.11 mM/kg body weight) into conscious thyroidectomized pigs elicits a 30% rise in both ionized and total calcium concentrations of plasma, which return to basal levels within 180 min. The administration of calcitonin (2.5-10 MRC U/kg body weight) reduces this time to 30...

journal_title：Journal of endocrinological investigation

authors： Jaros GG,Van Hoorn-Hickman R,Maier H,Newman E

更新日期：1983-04-01 00:00:00

abstract：:Few data are available on serum free thyroid hormone concentration in patients with T3-toxicosis. In this study total and free T4 and T3 and TBG were evaluated in 35 subjects with T3-toxicosis, including 12 with untreated Graves' disease, 5 Graves' patients on methimazole treatment, 13 with autonomous adenoma, 3 with ...

journal_title：Journal of endocrinological investigation

authors： Ferrari C,Romussi M,Rampini P,Benco R,Boghen M,Paracchi A,Frezzati S

更新日期：1983-02-01 00:00:00

abstract：:The authors report the profiles of luteinizing hormone (LH), estradiol (E2), progesterone (P) and androstenedione (A) in some female pigs with altered plasma hormonal levels. Twenty cycles are described and 19 out of them are characterized by low plasma P in luteal phase of different etiology, at least as measured by ...

journal_title：Journal of endocrinological investigation

authors： Pierantoni R,Genazzani AR,Perotti L,Enne G,Inaudi P,d'Istria M,Musarò MA,Citarella F,Fasano S,Delrio G

更新日期：1983-02-01 00:00:00

abstract：:ACTH, beta lipotropin (beta LPH), beta endorphin (beta EP), Prolactin (PRL) and Cortisol were measured in the first five days of puerperium at 9:00, before and 30 minutes after suckling, in 7 healthy lactating women. With the exception of PRL plasma levels which decline, although remaining at high concentrations durin...

journal_title：Journal of endocrinological investigation

authors： Genazzani AR,Facchinetti F,Parrini D,Petraglia F,La Rosa R,Puggioni R,D'Antona N

更新日期：1982-11-01 00:00:00

abstract：:Plasma insulin immunoreactivity (IRI) results from high molecular weight substances with insulin immunoreactivity (HWIRI), proinsulin (PI) and insulin (I). Their respective concentrations and percentages of IRI were determined preoperatively in the hepatic and peripheral circulations and after surgery in the latter tw...

journal_title：Journal of endocrinological investigation

authors： Villaume C,Beck B,Pointel JP,Drouin P,Debry G

更新日期：1982-09-01 00:00:00

abstract：:Prolactin, growth hormone and thyroid stimulating hormone responses to thyrotropin releasing hormone (TRH) and metoclopramide were determined in 12 alcoholic men with biopsy proven liver disease and were compared to those of 8 age matched normal controls. All subjects were challenged with TRH (400 micrograms) and meto...

journal_title：Journal of endocrinological investigation

authors： Van Thiel DH,Gavaler JS,Sanghvi A

更新日期：1982-09-01 00:00:00

abstract：:In mature female rats the administration of testosterone led to a striking reduction of hepatic alcohol dehydrogenase activity, whereas the hepatic microsomal ethanol oxidizing system as well as catalase were both increased in activity under these experimental conditions. Conversely, estradiol left the activities of a...

journal_title：Journal of endocrinological investigation

authors： Teschke R,Wiese B

更新日期：1982-07-01 00:00:00

abstract：:A 50 year old man is described in whom primary hypothyroidism and isolated ACTH deficiency leading to adrenocortical insufficiency occurred simultaneously. Low thyroid hormone levels, elevated serum TSH values and high titers of antithyroid antibodies (ATA) were consistent with primary hypothyroidism. The diagnosis of...

journal_title：Journal of endocrinological investigation

authors： Roosens B,Maes E,Van Steirteghem A,Vanhaelst L

更新日期：1982-07-01 00:00:00

abstract：:We studied 8 insulin dependent stable young diabetics with a mean age of 20 yr. Each patient received 10 mg of diazepam orally after with drawing the baseline blood sample. Subsequent samples were obtained at 30 min intervals for 150 min. The oral administration of diazepam resulted in a significant increase in serum ...

journal_title：Journal of endocrinological investigation

authors： Ajlouni K,El-Khateeb M,El-Zaheri MM,El-Najdawi A

更新日期：1982-05-01 00:00:00

abstract：:Recently, bromocriptine has been successfully introduced as medical therapy for the pituitary hypersecreting syndromes of hyperprolactinemia and acromegaly. Subsequently, an inhibitory effect on ACTH secretion was reported using bromocriptine in Cushing's disease. While most studies have focused on the acute response ...

journal_title：Journal of endocrinological investigation

authors： Kapcala LP,Jackson IM

更新日期：1982-03-01 00:00:00

abstract：:The changes occurring in the levels of circulating thyroid microsomal antibody (M-Ab) and antithyroglobulin antibody (Tg-Ab) during antithyroid drug therapy were studied in 32 patients receiving methimazole for Graves' disease. M-Ab was determined by competitive binding radioassay and Tg-Ab by a sandwich radiometric m...

journal_title：Journal of endocrinological investigation

authors： Marcocci C,Chiovato L,Mariotti S,Pinchera A

更新日期：1982-01-01 00:00:00

abstract：:We have developed a sandwich-type enzyme immunoassay for human chorionic gonadotropin (hCG), in which antibody Fab'-beta-D-galactosidase complex and an antibody-immobilized silicone rubber solid phase were used. Despite the fact this assay system crossreacted about 40% with human luteinizing hormone (LH) that contains...

journal_title：Journal of endocrinological investigation

authors： Sekiya T,Furuhashi Y,Goto S,Kaseki S,Tomoda Y,Kato K

更新日期：1981-07-01 00:00:00

abstract：:Human thyroid blood flow rate (TBF) was measured during operations by electromagnetic flowmetry in 75 euthyroid patients with normal thyroid tissue, nodular goiter, or solitary adenoma, and in 22 hyperthyroid patients with diffuse or nodular goiter. Blood flow rate was measured in one to four of the thyroid arteries. ...

journal_title：Journal of endocrinological investigation

authors： Tegler L,Gillquist J,Anderberg B,Lundström B,Johansson H

更新日期：1981-07-01 00:00:00

abstract：:The usefulness of solubilized TSH-receptor for measuring TSH and TSH-displacing antibodies (TDA) in a radioligand receptor assay (RRA) was investigated. Crude thyroid membranes were solubilized with Triton X-100. A soluble protein fraction was isolated by DEAE-Sephadex A-50 ion-exchange chromatography. The binding of ...

journal_title：Journal of endocrinological investigation

authors： Kotulla P,Schleusener H

更新日期：1981-04-01 00:00:00

abstract：:The Authors have studied the effects of somatostatin (SRIF) treatment in an infant affected by hypoglycemia due to nesidioblastosis. During iv infusion with SRIF we observed a marked increase of blood glucose levels; concomitantly insulin secretion was almost completely suppressed. In contrast, during treatment with p...

journal_title：Journal of endocrinological investigation

authors： Roti E,Ghinelli C,Bandini P,Del Rossi C,Emanuele R,Robuschi G,Gnudi A

更新日期：1981-04-01 00:00:00

abstract：:The present experiments were undertaken to study the effect of complete food removal on body weight, pituitary growth hormone (GH), plasma GH and glucose concentration in male and female Wistar rats. Plasma and pituitary GH levels were measured by means of a specific radioimmunoassay. Plasma glucose concentration decr...

journal_title：Journal of endocrinological investigation

authors： Gonzalez C,Jolin T

更新日期：1981-01-01 00:00:00

abstract：:Although the role of biogenic amines in the regulation of gonadotropin release has been studied extensively, the precise role of dopamine (DA) in stimulating LHRH and/or LH release is still controversial. In the present study 6 eugonadal women, aged 20-30, were given an LHRH infusion on day 6 of the menstrual cycle an...

journal_title：Journal of endocrinological investigation

authors： Pucci E,Franchi F,Kicovic PM,Sgrilli R,Barletta D,Argenio GF,Gasperi M,Bernini GP,Luisi M

更新日期：1981-01-01 00:00:00

abstract：:The behavior of serum anti-thyroglobulin (Abs-Tg) and antimicrosomal antibodies (Abs-Mc) was examined during and after normal pregnancies. The antibodies titer decreases as pregnancy progresses; they cross the placenta and are present in the fetal serum. Infants' thyroid function is not affected by this transplacentar...

journal_title：Journal of endocrinological investigation

authors： D'Armiento M,Salabé H,Vetrano G,Scucchia M,Pachi A

更新日期：1980-10-01 00:00:00

abstract：:To assess the role of the renin-angiotensin system in the control of aldosterone reease in response to heat exposure, 6 sodium restricted subjects were studied on three random experimental days: a control day and two heat exposure days (46C, 35 mbar, 90 min) with and without propranolol. Plasma aldosterone, renin acti...

journal_title：Journal of endocrinological investigation

authors： Brandenberger G,Follenius M,Oyono S

更新日期：1980-10-01 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH)-like material was found in human retina obtained at autopsy from eyes used for corneal grafts. The TRH-like material was extracted with methanol and was found to be indistinguishable from synthetic TRH in its immunoreactivity and bioreactivity and in its proteolytic degradation by f...

journal_title：Journal of endocrinological investigation

authors： Martino E,Nardi M,Vaudagna G,Simonetti S,Cilotti A,Pinchera A,Venturi G,Seo H,Baschieri L

更新日期：1980-07-01 00:00:00

abstract：:A possible participation of central serotoninergic or noradrenergic neurons on nyctohemeral periodicity of plasma TSH concentration was studied in the rat. Control rats exhibited normal nyctohemeral fluctuations of plasma TSH characterized by high AM (09:30) and low PM (18:30) values (397 +/- 45 vs. 207 +/- 28 ng/ml, ...

journal_title：Journal of endocrinological investigation

authors： Fukuda H,Mori M,Ohshima K,Kobayashi I

更新日期：1980-07-01 00:00:00

abstract：:The effect of the somatostatin analog (GHRIH-A) D-Trp8, D-Cys14 on plasma levels of growth hormone, pancreatic glucagon, insulin and glucose was studied in four acromegalic patients and in four maturity-onset mild diabetics. Acromegalics received a bolus iv injection of 25 microgram of GHRIH-A, followed by a continuou...

journal_title：Journal of endocrinological investigation

authors： Trovati M,Massara F,Camanni F,Molinatti GM,Lorenzati R,Pagano GF

更新日期：1980-04-01 00:00:00

abstract：:The possible role of the renin-angiotensin system and ACTH in controlling the temporal organization of circadian rhythm of aldosterone was studied in patients with mesor-hypertension (MH) by simultaneous radioimmunological determinations of within-day changes in plasma renin, aldosterone and cortisol. Thirty-nine unco...

journal_title：Journal of endocrinological investigation

authors： Cugini P,Manconi R,Serdoz R,Mancini A,Meucci T,Scavo D

更新日期：1980-04-01 00:00:00

abstract：:The TSH responses to the catecholamine depleting agent monoiodotyrosine (1 g po) and the dopamine receptor blocking drug metoclopramide (10 mg po) have been compared in euthyroid and hypothyroid subjects. Both drugs lead to a prompt and significant rise in TSH levels (peak values at 60-75 min) which is very much great...

journal_title：Journal of endocrinological investigation

authors： Scanlon MF,Rodriguez-Arnao MD,Pourmand M,Shale DJ,Weightman DR,Lewis M,Hall R

更新日期：1980-04-01 00:00:00

abstract：:Insulin degradation in IM-9 cultured human lymphocytes occurs extracellularly. In the presence of 0.1% bovine serum albumin, insulin degradation products are formed that are soluble in 5% trichloroacetic acid. In the presence of 5% bovine serum albumin, the major products of insulin degradation are insoluble in 5% tri...

journal_title：Journal of endocrinological investigation

authors： Misbin RI,Mehl TD

更新日期：1980-01-01 00:00:00

abstract：:The calcitonin (CT) concentration has been determined in the serum of 17 patients with different pituitary diseases. More or less elevated levels were found in 7 of them. No definite correlation has been observed between the immunoreactive CT and the different pituitary hormones. ...

journal_title：Journal of endocrinological investigation

authors： Ziliotto D,Luisetto G,Cecchini M,Gastaldo M,Francia G,Padovan L,Heynen G

更新日期：1980-01-01 00:00:00